The Environmental Mutagen Society of Japan NII - Electronic Library Service
نویسنده
چکیده
and singlet oxygen. ROS is also generated in cells by exposure to radiation and chemical carcinogens, Because ROS damages nearby cellular components such as DNA, proteins and lipids in mernbrane, cells must have evolved multiple defense mechanisms to combat the oxidative stress, Enzymes such as catalase or superoxide dismutase detoxify ROS, and low-molecular-weight scavengers such as glutathione alleviate the toxicity of ROS. Nevertheless, some ROS molecules escape from the defense systems and inevitably damage the biomolecules. DNA repair mechanisms, e.g,, 8-hydroxyguanine (8-OH-G) DNA glycosylase encoded by OGGI in humans and mutM in EScherichia coti, remove the damage and convert the modified bases to unmodified
منابع مشابه
Second International Conference on Environment Mutagens in Human Populations. Proceedings. Prague, Czech Republic, August 20-25, 1995.
The Second International Conference on Environmental Mutagens in Human Populations was held in Prague, Czech Republic, 20-25 August 1995. The conference was organized by Radim J. Sram, William W. Au, the Czech and Slovak Society of Environmental Mutagenesis, the Czechoslovak Biological Society, the Environmental Mutagen Society, the European Environmental Mutagen Society, the International Asso...
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